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Compared with IL12 mRNA-loaded liposomes, aerosolized exosomes demonstrated better mucus penetration 214,215 , resulting in notable immunogenicity

doi: 10.14814/phy2.14373 49 HjelholtAJSndergaardEPedersenSBMllerNJessenNJrgensenJOL

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Senescent microglia may have a reduced capacity to modulate neuronal activity because of genetic changes that result in reduced surveillance, migration, and sensitivity to endogenous ligands, and a heightened sensitivity to pathogens, as seen in 24-month-old mice (Hickman et al., 2013